Determinants of quality of life in children with Gilles de la Tourette syndrome
Identifieur interne : 000B18 ( Main/Exploration ); précédent : 000B17; suivant : 000B19Determinants of quality of life in children with Gilles de la Tourette syndrome
Auteurs : Bryan A. Bernard [États-Unis] ; Glenn T. Stebbins [États-Unis] ; Sandra Siegel [États-Unis] ; Theresa M. Schultz [États-Unis] ; Cynthia Hays [États-Unis] ; Mary J. Morrissey [États-Unis] ; Sue Leurgans [États-Unis] ; Christopher G. Goetz [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-05-15.
English descriptors
Abstract
The objective of this study is to assess the association between tic severity, attention deficit disorder, obsessive‐compulsive behavior, and quality of life (QOL) in children with Gilles de la Tourette syndrome (GTS). GTS is a multidimensional disorder with disturbances in motor function and behavior. However, little is known about what variables are associated with QOL in these patients. We evaluated 56 outpatients with a diagnosis of GTS. The mean age was 10 (range 5–17 years). Tics were assessed with the Yale Global Tic Severity Scale (YGTSS). Behavioral scales included the Leyton Obsessional Inventory—Child Version, Children's Yale‐Brown Obsessive Compulsive Scale (CY‐BOCS), and Attention‐Deficit/Hyperactivity Disorder (ADHD) rating scale. The patient's parent also completed the TNO‐AZL Children's Quality of Life scale (TACQOL). YGTSS scores ranged from 4 to 30, indicating mild to moderate tic severity. Motor and phonic tic ratings were not correlated with QOL. However, both ADHD and OCD were significantly related to QOL. Subanalysis of ADHD subtypes demonstrated that inattentiveness but not hyperactivity predicted lower QOL. When ADHD, Leyton OCD, and tic severity were considered simultaneously, tic severity remained non‐significant, while both ADHD and OCD remained significant contributors to QOL. In summary, in patients with mild to moderate GTS, QOL relates primarily to co‐morbidities of ADHD and obsessive‐compulsive behavior. ADHD with predominantly inattentive symptoms, rather than hyperactivity symptoms, was associated with lower QOL. To improve QOL, clinicians must consider treatments of co‐morbidities among tic patients. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22487
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determinants of quality of life in children with Gilles de la Tourette syndrome</title><author><name sortKey="Bernard, Bryan A" sort="Bernard, Bryan A" uniqKey="Bernard B" first="Bryan A." last="Bernard">Bryan A. Bernard</name></author><author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name></author><author><name sortKey="Siegel, Sandra" sort="Siegel, Sandra" uniqKey="Siegel S" first="Sandra" last="Siegel">Sandra Siegel</name></author><author><name sortKey="Schultz, Theresa M" sort="Schultz, Theresa M" uniqKey="Schultz T" first="Theresa M." last="Schultz">Theresa M. Schultz</name></author><author><name sortKey="Hays, Cynthia" sort="Hays, Cynthia" uniqKey="Hays C" first="Cynthia" last="Hays">Cynthia Hays</name></author><author><name sortKey="Morrissey, Mary J" sort="Morrissey, Mary J" uniqKey="Morrissey M" first="Mary J." last="Morrissey">Mary J. Morrissey</name></author><author><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7386C94858DD2B69BC1FF8C327BB0891EE5E2125</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22487</idno><idno type="url">https://api.istex.fr/document/7386C94858DD2B69BC1FF8C327BB0891EE5E2125/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001C30</idno><idno type="wicri:Area/Main/Curation">001959</idno><idno type="wicri:Area/Main/Exploration">000B18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Determinants of quality of life in children with Gilles de la Tourette syndrome</title><author><name sortKey="Bernard, Bryan A" sort="Bernard, Bryan A" uniqKey="Bernard B" first="Bryan A." last="Bernard">Bryan A. Bernard</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Siegel, Sandra" sort="Siegel, Sandra" uniqKey="Siegel S" first="Sandra" last="Siegel">Sandra Siegel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Stress Control, Hinsdale, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Schultz, Theresa M" sort="Schultz, Theresa M" uniqKey="Schultz T" first="Theresa M." last="Schultz">Theresa M. Schultz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Dominican University, River Forest, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hays, Cynthia" sort="Hays, Cynthia" uniqKey="Hays C" first="Cynthia" last="Hays">Cynthia Hays</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Stress Control, Hinsdale, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Morrissey, Mary J" sort="Morrissey, Mary J" uniqKey="Morrissey M" first="Mary J." last="Morrissey">Mary J. Morrissey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-05-15">2009-05-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1070">1070</biblScope><biblScope unit="page" to="1073">1073</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7386C94858DD2B69BC1FF8C327BB0891EE5E2125</idno><idno type="DOI">10.1002/mds.22487</idno><idno type="ArticleID">MDS22487</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>movement disorders</term><term>neuropsychology/behavior</term><term>pediatric disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study is to assess the association between tic severity, attention deficit disorder, obsessive‐compulsive behavior, and quality of life (QOL) in children with Gilles de la Tourette syndrome (GTS). GTS is a multidimensional disorder with disturbances in motor function and behavior. However, little is known about what variables are associated with QOL in these patients. We evaluated 56 outpatients with a diagnosis of GTS. The mean age was 10 (range 5–17 years). Tics were assessed with the Yale Global Tic Severity Scale (YGTSS). Behavioral scales included the Leyton Obsessional Inventory—Child Version, Children's Yale‐Brown Obsessive Compulsive Scale (CY‐BOCS), and Attention‐Deficit/Hyperactivity Disorder (ADHD) rating scale. The patient's parent also completed the TNO‐AZL Children's Quality of Life scale (TACQOL). YGTSS scores ranged from 4 to 30, indicating mild to moderate tic severity. Motor and phonic tic ratings were not correlated with QOL. However, both ADHD and OCD were significantly related to QOL. Subanalysis of ADHD subtypes demonstrated that inattentiveness but not hyperactivity predicted lower QOL. When ADHD, Leyton OCD, and tic severity were considered simultaneously, tic severity remained non‐significant, while both ADHD and OCD remained significant contributors to QOL. In summary, in patients with mild to moderate GTS, QOL relates primarily to co‐morbidities of ADHD and obsessive‐compulsive behavior. ADHD with predominantly inattentive symptoms, rather than hyperactivity symptoms, was associated with lower QOL. To improve QOL, clinicians must consider treatments of co‐morbidities among tic patients. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Bernard, Bryan A" sort="Bernard, Bryan A" uniqKey="Bernard B" first="Bryan A." last="Bernard">Bryan A. Bernard</name></region><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><name sortKey="Hays, Cynthia" sort="Hays, Cynthia" uniqKey="Hays C" first="Cynthia" last="Hays">Cynthia Hays</name><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name><name sortKey="Morrissey, Mary J" sort="Morrissey, Mary J" uniqKey="Morrissey M" first="Mary J." last="Morrissey">Mary J. Morrissey</name><name sortKey="Schultz, Theresa M" sort="Schultz, Theresa M" uniqKey="Schultz T" first="Theresa M." last="Schultz">Theresa M. Schultz</name><name sortKey="Siegel, Sandra" sort="Siegel, Sandra" uniqKey="Siegel S" first="Sandra" last="Siegel">Sandra Siegel</name><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B18 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B18 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:7386C94858DD2B69BC1FF8C327BB0891EE5E2125
|texte= Determinants of quality of life in children with Gilles de la Tourette syndrome
}}
| This area was generated with Dilib version V0.6.23. |  |